Rejuran® PDRN Skin Booster in San Francisco, CA

Reveal Healthier, More Radiant Skin with Rejuran® PDRN Skin Booster

Experience the restorative potential of Rejuran® PDRN Skin Booster at Rejuv Medical in San Francisco, CA. Formulated with Polydeoxyribonucleotide (PDRN) — a biocompatible compound derived from highly purified salmon DNA — this skin booster service is designed to support your skin's own renewal processes, promoting a smoother, more luminous, and deeply hydrated complexion from within.

Please note: Rejuran® PDRN is not FDA-approved for cosmetic injection use in the United States. At Rejuv Medical, we believe in complete transparency — your provider will walk you through everything during your consultation so you can make a fully informed decision.

Provider performing a Rejuran PDRN skin booster treatment on a patient's cheek

Benefits of Rejuran® PDRN Skin Booster

Targeted Cellular Renewal

PDRN works at the intradermal level to support the skin's natural repair processes. By promoting cellular regeneration, it may help improve skin texture, reduce the appearance of fine lines, and restore a more youthful, even-toned complexion over time.

Deep Hydration and Radiance

Unlike topical moisturizers, Rejuran® PDRN is delivered directly into the skin, where it may support moisture retention and elasticity from within. Clients often notice a visible improvement in skin plumpness and a natural, healthy glow following their sessions.

Biocompatible and Gentle

PDRN is derived from highly purified salmon DNA and is biocompatible with human tissue. It is designed to work in harmony with your skin's own biology, making it a well-tolerated option for a wide range of skin types and concerns.

Understanding Our Rejuran® PDRN Process

  1. Consultation

    At Rejuv Medical, every Rejuran® PDRN session begins with a one-on-one consultation to discuss your skin concerns, goals, and health history. This step ensures the service is a suitable fit for you and allows us to personalize your experience.

  2. Comfort and treatment

    Before your session begins, a topical numbing cream is applied to maximize your comfort. Rejuran® is then delivered via precise micro droplet placement and intradermal infusion, targeting the deeper layers of the skin where cellular repair and renewal occur. This technique ensures even distribution of PDRN throughout the treatment area for consistent results.

  3. After your session

    A full session typically takes 30 to 45 minutes. Most clients experience mild redness or slight swelling immediately following the session, which generally resolves within 24 to 48 hours. There is no significant downtime, and most clients return to their normal activities the same day.

  4. Your series

    For optimal results, we recommend a series of 3 to 4 sessions spaced 3 to 4 weeks apart, followed by maintenance sessions every 3 to 6 months. Your provider will develop a personalized plan based on your individual skin goals.

Rejuran® PDRN Skin Booster is available as a standalone service and can also be combined with other offerings at Rejuv Medical, such as microneedling or dermal fillers, where appropriate. Your provider will advise on the best approach for your skin.

Provider performing a precise Rejuran micro droplet treatment at REJUV Medical

Rejuran® Eye for the Under-Eye Area

Rejuran® is also well suited for the delicate under-eye area. Rejuran® Eye — our 1 mL under-eye formulation — may help address the appearance of dark circles, hollowness, and mild puffiness for clients who are not yet ready for, or interested in, dermal fillers or PRF.

The under-eye area is treated with the same precise micro droplet placement and intradermal infusion technique, adapted for the thinner, more sensitive tissue around the eye. This makes it a gentle, lower-commitment option for clients looking to refresh tired-looking eyes without a more invasive approach.

Rejuran PDRN skin booster box and syringes beside a smiling woman

Essential Aftercare Tips

Following your Rejuran® PDRN session at Rejuv Medical, please observe these aftercare guidelines to support your skin's recovery and help you get the most from your experience.

  • Avoid touching the treated area for at least 6 hours after your session to minimize the risk of irritation or infection.
  • Skip makeup for the first 24 hours to allow your skin to breathe and recover undisturbed.
  • Apply SPF 30 or higher daily, beginning the morning after your session. Sun protection is essential to protect the skin while it is in a renewal phase.
  • Avoid vigorous exercise, saunas, and steam rooms for 48 hours following your session, as heat and sweat can aggravate sensitivity.
  • Stay well hydrated in the days following your session to support your skin from the inside out.
  • Avoid harsh skincare products — including retinoids, exfoliating acids, and strong active ingredients — for at least 72 hours post-session. Stick to a gentle cleanser and hydrating moisturizer.

If you experience any unusual symptoms, prolonged swelling, or discomfort beyond 48 hours, please contact our office.

Relaxed patient receiving a gentle Rejuran skin booster treatment

Rejuran® PDRN Pricing

Natural skin renewal from within — no synthetic fillers.

Treatment Price
Rejuran® Healing Essence — 2 mL (face) $599
Rejuran® Eye — 1 mL (under-eye area) $349

For optimal results, a series of 3–4 sessions spaced 3–4 weeks apart is recommended. Rejuran® PDRN is not FDA-approved for cosmetic injection use in the United States. Please consult with your provider to determine whether this service is right for you.

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Frequently Asked Questions

Rejuv Medical is committed to ensuring our clients have all the information they need about Rejuran® PDRN Skin Booster. Here are some of the most frequently asked questions and their answers.

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What is PDRN?

PDRN stands for Polydeoxyribonucleotide. It is a biocompatible compound derived from highly purified salmon DNA that is used in aesthetic medicine to support tissue repair, skin hydration, and cellular regeneration. It is widely used in South Korea and across Asia, where it has been extensively studied.

Is Rejuran® FDA-approved?

Rejuran® PDRN is not currently FDA-approved for cosmetic injection use in the United States. It has received approval and widespread clinical use in South Korea and other countries. At Rejuv Medical, we are committed to full transparency — we encourage every client to discuss their questions, health history, and any concerns openly with our provider before deciding whether this service is right for them.

Who is a good candidate for Rejuran® PDRN Skin Booster?

Rejuran® may be a suitable option for adults looking to support overall skin quality, address early signs of aging, improve skin hydration and texture, or complement other aesthetic services. It is not recommended for individuals who are pregnant or breastfeeding, have active skin infections, or have known allergies to salmon or fish-derived products. A consultation is required prior to your first session.

How soon will I see results?

Many clients notice an improvement in skin texture and hydration within 2 to 4 weeks of their first session. More visible improvements in skin tone and fine lines are typically seen after a series of sessions. Individual results vary.

Can Rejuran® be combined with other services?

Rejuran® PDRN can complement a range of other services we offer, including microneedling and dermal fillers, in some cases. Your provider will advise on any recommended intervals between services during your consultation.

How long do results last?

Results vary by individual. Following a recommended series of 3 to 4 initial sessions, many clients maintain their results with follow-up sessions every 3 to 6 months.

Can Rejuran® help with dark circles and eye bags?

Rejuran® Eye is a 1 mL formulation specifically designed for the under-eye area. Delivered via the same precise micro droplet placement and intradermal infusion technique, it may help support the appearance of dark circles, fine lines, and mild under-eye puffiness over a series of sessions. It is a particularly good option for clients who want to address early signs of under-eye aging without committing to dermal fillers or PRF. Individual results vary, and a consultation with your provider is the best way to determine whether it is the right fit for your goals.

How is Rejuran® Eye different from dermal fillers or PRF for the under-eye area?

Dermal fillers add immediate volume to the under-eye area, while PRF uses your own plasma to stimulate gradual regeneration. Rejuran® Eye takes a different approach — it works at the cellular level to support hydration, skin quality, and tissue health in the under-eye area. It does not add volume the way a filler does, which makes it a great option for clients with mild concerns, those who prefer a more conservative first step, or those who want to maintain results between filler appointments. Your provider will help you understand which approach best fits your specific goals.

Ready to Support Your Skin's Natural Renewal?

If you're curious about Rejuran® PDRN Skin Booster and whether it may be the right fit for your skin goals, we'd love to connect. Book a consultation with Katerina Helmn, FNP, at Rejuv Medical in San Francisco, and we'll walk you through everything — honestly and thoroughly.

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*Individual results may vary.